Detection of 8-hydroxy-2'-deoxyadenosine and 8-hydroxy-2'-deoxyguanosine by avidin
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چکیده
منابع مشابه
Urinary Sulfate, Asymmetric Dimethylarginine, and 8-Hydroxy-2'-Deoxyguanosine:
Compounds found in the urine represent the end products of metabolism and are the expression of the efficiencies or inefficiencies of this process. Nutritional status has a direct effect on this metabolic efficiency. Careful assessment of certain urinary compounds can yield valuable information on the nutrient needs of the individual. Urinary sulfate, asymmetric dimethylarginine (ADMA), and 8-h...
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The asymmetric unit of the title compound, C(10)H(9)NO, contains two independent mol-ecules which are linked by a pair of O-H⋯N hydrogen bonds into a hydrogen-bonded dimer.
متن کاملDetermination of 8-hydroxy-2'deoxyguanosine in urine using HPLC with electrochemical detection.
Endogenous cell metabolism and different chemicals, drugs, ionising radiation, solar light, cigarette smoking, and air pollution can induce oxidative damage to DNA. Oxidative DNA damage is involved in the development of different diseases, aging, and cancer. Urine 8-hydroxy-2'deoxyguanosine (8-oxodG) is widely accepted as a biomarker of the "whole body" oxidative DNA damage. The aim of this stu...
متن کاملIncreased 8-hydroxy-2’-deoxyguanosine in leukocyte DNA from patients with type 2 diabetes and microangiopathy
OBJECTIVE To evaluate oxidative damage in leukocytes from patients with type 2 diabetes by examining 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels. METHODS Patients with type 2 diabetes and healthy controls were assessed for demographic, clinical and biochemical characteristics. Levels of 8-OHdG in extracted leukocyte DNA were determined by enzyme linked immunosorbent assay. RESULTS Of 108 pa...
متن کاملSuppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5.
To assess the functions of the three human MutT-type enzymes, MTH1, MTH2, and NUDT5, mutation induction by an oxidized form of dGTP, 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (8-OH-dGTP; 7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate), was examined using human 293T cells treated with their specific siRNAs. Shuttle plasmid DNA containing the supF gene was first transfected into the cells,...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2005
ISSN: 0108-7673
DOI: 10.1107/s010876730509063x